Antigen delivery to lymph node-resident antigen presenting cells is critical for the efficient induction of anti-tumor immunity by therapeutic cancer vaccines. Our hydrophobized polysaccaride-based delivery system, CHP greatly improves the delivery of peptide/protein antigen to the lymph nodes, antigen-specific T cell response and inhibitory effect on in vivo tumor growth.
Regulatroy T cell can be generated using dendritic cells transfected with siRNA in vitro. Also, antigen-specific regulatory T can be generated using dendritic cells transfected with siRNA and pulsed with antigen.
Two natural compounds with potent agonist activity for retinoid X receptor were isolated from Sophora tonkinensis. These natural compounds are expected to produce novel agents to prevent or treat lifestyle-related illness or ulcerative colitis.
We found that baculovirus produces a novel chondroitinase with distinct substrate specifisity, and chondroitin sulfate exists in midgut peritropic membrane of insect. These are suggested that the baculovirus chondroitinase works at initial infection of virus to insect.
We introduce a novel protein stably overexpressed in urothelial carcinoma cells of the uinary bladder, ureter or renal pelvis in contrast to less expression in non-neoplastic cells. Application of protein immunolabeling to urine cytology will be a new diagnostic tool for human cancer arising in the urinary tract.
Forcussed are novel techniques for preparation of recombinant proteoliposomes and ultrasonicated proteoliposomes, which make usually water-insoluble membrane proteins into in vivo soluble states with high functionality. They are applicable for original developments in diagnosis, treatment and prevention of diseases as well as drug discovery.