It was observed that gluten-free rice bread exhibited excellent swelling; even without a gluten membrane; when baked with soy milk instead of water, and with the addition of egg white protein. In addition, the bread had a very fine structure and crumbs and crust softness that were previously impossible with gluten-free rice bread.
We are aiming at development of novel 2-decenoic acid derivatives as drugs for neurological disorders based on facilitation of neurotrophic factor signaling. Neurological disorders include Alzheimer's disease, stroke, depression, spinal cord injury and neuropathic pain.
We have found a new method for efficient preparation of sterically highly hindered metalloporphyrins that have 2,6-diarylphenyl moieties at their meso positions. Ruthenium complexes of the porphyrins catalyze selective ω-1 oxidation of linear alkane.The metalloporphyrins we developed are expected to be used for other various C-H activation process with unique selectivity.
When clarithromycin metastable crystal forms such as form I and 0 were mixed with hydroxy propyl methyl cellulose (HMPC) without using special additives and the mixture was then tabletted, a tablet which can float for several hours in the solutions enable to be prepared.
We discovered that baccharin, a component of Brazilian propolis, selectively inhibits aldo-keto reductase (AKR) 1C3, which participates in androgen synthesis. Here, we have succeeded the development of more potent and selective AKR1C3 inhibitors based on baccharin.
Cancer cell selective Photodynamic therapy (PDT) by using novel glucose-conjugated photosensitizer, which utilizes the phenomenon that cancer cells uptake much glucose, revealed very strong antitumor effects. PDT by using mannose-conjugated photosensitizer which targets tumor associated macrophages (TAMs) in cancer stroma revealed stronger antitumor effects than glucose-conjugated photosensitizer.