Reversible topographical changes are observed on a photochromic diarylethene microcrystalline film surface by alternate irradiation with UV and visible light. The crystals of closed- or open-ring isomers of the diarylethenes were grown from the eutectic mixtures of both isomers by UV or visible light irradiations. The photogenerated crystals form either needle-shape or cubic-shape. The former surfaces show a superhydrophobic wetting property, while the latter does not show such superhydrophobicity. We further developed a epitaxial crystal growth of the closed-ring isomer on the lattice of the open-ring isomer of a diarylethene derivative. On the photoinduced surface, needle-shaped crystals stood well-ordered and it showed superhydrophobic lotus effect as well as the antireflection moth-eye effect.
Past-like calcium phosphate cements has attracted considerable attention owing to their biocompatibility, injectability, and ease of handling. To shorten the hardening period and enhance the compressive strength of bone cements, ternary calcium phosphate cements prepared by adding TTCP and DCPD to β-TCP. The ternary cement with a particular ratio dispayed early hardening and sufficiently improved compressive strength.
We found that a subset of peptides binding to the amino terminus of C99 inhibited Aβ production in a substrate-specific manner. Our data demonstrate that the ectodomain of C99 is a potent target for substrate-specific anti-Aβ therapeutics to combat Alzheimer's disease (Funamoto et al., Nat. Commun. 2013).
Effective protein crystallization methods by using small molecules such as specific amino acids and amino acid derivatives were developed. In addition, glutathione derivatives, effective refolding agents, were also developed.
This system detects obstacles and/or holes on the road by using depth sensor such as Kinect or Xtion. The sensor is assumed to be attached to a mobile body such as a human body or a cart, and the posture of the sensor is estimated in real time from the observed data.